P o 2 is plotted on the xaxis from 0 to 100 mm hg millimeters of mercury. Oxygen hemoglobin dissociation curve explained duration. The degree of o 2 hemoglobin binding o 2 saturation is represented by the oxygen hemoglobin dissociation curve. Oxygen dissociation curve an overview sciencedirect topics. The rate of sickle cell formation and its reversal were determined under conditions of deoxygenation and oxygenation. Oxygen dissociation curves free download as powerpoint presentation. States the physiologic consequences of the shape of the oxyhemoglobin dissociation curve. Lists the physiologic factors that can influence the oxyhemoglobin dissociation curve, and predicts their effects on oxygen transport by the blood. To examine mechanisms underlying the exceptional diving ability of this species and further describe blood oxygen o2 transport and depletion while diving, we characterized the o2 hemoglobin hb dissociation curve. Chemeketa community college oxygenhemoglobin dissociation curve. Ppt respiratory gas transport powerpoint presentation.
If the curve is shifted to the right, p 50 is increased and oxygen affinity is decreased oxygen unloading is increase. Odcs in a theoretical healthy subject with a normal blood haemoglobin hb. The p50 is a conventional measure of hemoglobin affinity for oxygen. Configuration of the hemoglobin oxygen dissociation curve. Causes of asthma and its effects on the gas exchange system. The oxygen dissociation curve has a sigmoid shape because of the cooperative binding of oxygen to the 4 polypeptide chains. The oxygen dissociation curve plots the % saturation against the partial pressure of oxygen, and its contribution to the total oxygen content. Hemoglobin is partially saturated when only some heme units are bound to oxygen. The three main points to indicate on the curve are. Curve c may represent the dissociation at lower than normal body temperature. Start studying oxygenhemoglobin dissociation curve. If this dissociation is graphed with po2 on the xaxis and percent so2 on the yaxis, the resulting curve is slightly s shaped.
Oxy hemoglobin dissociation curve is the property of its rightful owner. Oxygen hemoglobin dissociation curve all medical stuff. The test to identify congenital forms of erythrocytosis is measurement of the hemoglobin oxygen dissociation curve. Download figure open in new tab download powerpoint. Highaffinity hemoglobin and blood oxygen saturation in. An oxygen hemoglobin saturation dissociation curve is a common way to depict the relationship of how easily oxygen binds to or dissociates from hemoglobin as a function of the partial pressure of oxygen. Hemoglobin is the main protein within red blood cells, and its made of four globin subunits, each containing a. This curve is an important tool for understanding how our blood carries and releases oxygen. The oxygen dissociation curve odc of hemoglobin hb has been widely studied and.
Find powerpoint presentations and slides using the power of, find free presentations research about hemoglobin and myoglobin structure and function ppt. Diagnosing or ruling out polycythemia vera in patients. The oxygen dissociation curve odc of hemoglobin hb has been widely studied and mathematically described for nearly a century. The oxygen haemoglobin dissociation curve, also called the oxyhaemoglobin dissociation curve or oxygen dissociation curve odc, is a curve that plots the proportion of hemoglobin in its saturated oxygen laden form on the vertical axis against the prevailing oxygen tension on the horizontal axis. The key point to understand is that the bohr effect ensures a readily available supply of oxygen to respiring cells. An interactive demonstration of the concentration of oxygen in the blood plasma affecting oxygen hemoglobin saturation. Oxyhemoglobin dissociation curve powerpoint ppt presentation. Understanding the oxygen dissociation curve medical exam. Oxygen dissociation curves hemoglobin carbon dioxide. Several variables affect the carrying capacity of hemoglobin for oxygen table 92. Numerous mathematical models have been designed to predict with everincreasing accuracy the behavior of oxygen transport by hb in differing conditions of ph, carbon dioxide, temperature, hb levels, and 2,3diphosphoglycerate concentrations that enable their. As it binds to the iron atom in the center of the heme, it pulls a histidine amino acid upwards on the bottom side of the heme.
This relationship is reflected in the dissociation curve. Cooperative binding means that haemoglobin has a greater ability to bind oxygen after a subunit has already bound oxygen. Hemoglobin holds on to o2 until the o2 tension in the tissue is reduced to about 60 mm hg. A study of the sickling phenomenon and oxygen dissociation. Introduction the oxygen hemoglobin dissociation curve plots the proportion of hemoglobin in its saturated form on the vertical axis against the prevailing oxygen tension on the horizontal axis important tool for understanding how blood carries and releases oxygen 4. Proteinsmyoglobin and hemoglobin authorstream presentation. By comparing the experimental data so obtained with theoretically derived oxygen saturation curves for hemoglobin and isolated achains the values of the oxygen pairing energy and oxygen binding energy to hemoglobin molecule have been found to be 0. Relating oxygen partial pressure, saturation and content.
Factors that influence oxygen binding temperature increasing the temperature increases the amount of oxygen and hemoglobin and decreases the concentration of oxyhemoglobin. Schreve cardiopulmonary unit of the council for scientific and industrial research, department of medicine, university of the witwatersrand, johannesburg, south africa. If so, share your ppt presentation slides online with. When the curve moves to the left, the affinity of hemoglobin for oxygen. Adaptation to hypoxic environments at high altitudes, the air is thinner and therefore the partial pressure of oxygen is comparatively lower than closer to sea level. Convenient index of oxygen affinity partial pressure of oxygen at which hemoglobin is 12 or 50% saturated. Chemeketa community college oxygen hemoglobin dissociation curve oxyhemo curve the ability of oxygen to bind with and dissociate from hemoglobin how shifts change. Oxygen hemoglobin dissociation curve is the curve that describes the increase in the percentage of hemoglobin bound with oxygen as blood partial pressure of oxygen increases. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Oxygenhemoglobin dissociation curve how co affects oxy. The oxygen hemoglobin dissociation curve shows how the hemoglobin saturation with oxygen so2, is related to the partial pressure of oxygen in the blood po2.
The oxyhemoglobin dissociation curve is an important tool for understanding how our blood carries the oxygen form the alveoli and releases the oxygen into tissues. Oxygen dissociates from adult hemoglobin a1 in a characteristic fashion. The oxygen hemoglobin dissociation curve of each sample was plotted and the p50 determined with a hemoxanalyzer tcs, medical products division, southampton. Haemoglobin is, therefore, most attracted to oxygen when 3 of the 4 polypeptide chains are. Each haem group contains one iron atom, and one oxygen molecule binds to each iron atom. A free powerpoint ppt presentation displayed as a flash slide show on id. Myoglobin is a pigment that stores oxygen in the muscles. The emperor penguin aptenodytes forsteri thrives in the antarctic underwater environment, diving to depths greater than 500 m and for durations longer than 23 min. Oxyhemoglobin dissociation curve 2 important properties. The oxygen dissociation curves were found to be shifted to the right of the normal curve indicating a decreased affinity for oxygen.
Transport of oxygen oxygen is carried in red blood cells bound to haemoglobin. We then take a closer look at oxygen dissociation curves and. Find powerpoint presentations and slides using the power of, find free presentations research about oxygen dissociation curve ppt. S shaped curve shows the affinitity relation between. View and download powerpoint presentations on oxygen dissociation curve ppt. The reaction also causes the color of the rbcs in the vial to change from purple to red as shown in the animation. Oxygen haemoglobin dissociation curve 002 carrying capacity of hb at different p02 osigmoid shape 0binding of one molecule facilitate the second molecule. Hemoglobin function the normal hemoglobin molecule is well suited for its function allows for o 2 to be picked up at high o 2 tension in the lung and delivered to the tissues at low o 2 tension. The p50 represents the partial pressure at which the hemoglobin is 50% saturated with oxygen, typically 26. In this video, we look at the structure of haemoglobin and its role as a respiratory pigment. Studies of oxygen binding energy to hemoglobin molecule. Transport of oxygen and carbon dioxide in the blood. Parrots and parentsparrots and parents hemoglobin and oxygen act a little like parentshemoglobin and oxygen act a little like parents and children.
The oxygen dissociation curve is the expression of the relationship between the partial pressure of oxygen and oxygen saturation of haemoglobin. Defines hemoglobin saturation, the oxygen carrying capacity, and the oxygen content of blood. Myoglobin is a singlechain globular protein of 153or 154 amino acids, containing a heme ironcontaining porphyrin prosthetic group in the center around which the remaining apoprotein folds. The loading, transport and unloading of oxygen in relation to the oxygen dissociation curve. The haemoglobin molecule consists of four polypeptide chains, with a haem prosthetic group at the centre of each chain. The oxygen hemoglobin dissociation curve also called the oxyhemoglobin dissociation curve or oxygen dissociation curve odc, is a curve that plots the proportion of hemoglobin in its saturated oxygen laden form on the vertical axis against the prevailing oxygen tension on the horizontal axis. This curve may shift to left or right depending upon various factors which are described here. The oxygen dissociation curve of adult haemoglobin is a sigmoid curve.
Curve b below represents the oxygen hemoglobin dissociation curve for normal body temperature, arterial hydrogen ion concentration, and dpg concentration. Hemoglobin and myoglobin structure and function ppt. Oxyhemoglobin dissociation curve flashcards quizlet. Oxyhemoglobin dissociation curve is the property of its rightful owner. This is an s shaped curve due to the alterations in hemoglobin s affinity for oxygen in response to other physiologic factors. The p50 a common point of reference on the oxygen dissociation curve is the p50.
As o2 enters the vial of blood, the plasma po2 increases and more o2. So one haemoglobin molecule can bind up to 4 oxygen molecules. Oxygenhemoglobin dissociation curve flashcards quizlet. View and download powerpoint presentations on hemoglobin and myoglobin structure and function ppt. Oxygen dissociation curves ppt video online download slideplayer. Powerpoint slide on haemoglobin compiled by meenali mishra. If this curve is leftshifted low p 50, the patient has a high oxygen affinity hemoglobin mutant. View and download powerpoint presentations on function of haemoglobin ppt. This graph shows how changes in the partial pressure of oxygen p o 2 influence oxygen o 2 binding to, and dissociation from, hemoglobin hb. The bohr effect causes the oxygen hemoglobin dissociation curve to shift to the right.
854 427 1652 1578 132 304 300 226 1195 234 1375 1388 725 25 796 738 1472 62 974 565 1057 671 1393 1130 563 137 1206 891 334 379 394 658 380 1663 1569 960 608 1031 1002 67 1012 1183 66 1306 982 925 1470